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This functional change was corroborated by specific microbiota-metabolite associations: an increase in Bacteroidetes abundance was positively correlated with 2-acetylglutamate levels, while a decrease in Actinobacteria abundance was positively correlated with downregulation of indole-3-carboxylic acid, the latter of which may have triggered a compensatory upregulation of glycan biosynthesis and metabolism

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